Activated macrophages play an important role in many inflammatory diseases. However, the
molecular mechanisms controlling macrophage activation are not completely understood.
Here we report that a novel CCCH-zinc finger protein family, MCPIP1, 2, 3, and 4, encoded
by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates
macrophage activation. Northern blot analysis revealed that the expression of MCPIP1 and
MCPIP3 was highly induced in macrophages in response to treatment with …